N-Substituted metalloporphyrins as anti-tumor agents against PS-

Details N-Substituted metalloporphyrins as anti-tumor agents against PS- N-Substituted metalloporphyrins as anti-tumor agents against PS-

1981-07-01

1983-05-31

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31555

Patent

active

043860877

ABSTRACT:
Alkylating agents have been found to have chemotherapeutic value in cancer treatment. The difficulty of altering the alkylation rate or specificity of alkylating agents is solved by methyl release from metallo N-methyl porphyrins in which the release rate is determined by the particular metal ion of the complex. Moreover, it has been shown that porphyrins accumulate specifically in tumors. Sodium aquo-N-methyltetra (p-sulfophenyl) porphinatocopper (II) trifluoromethanesulfonate has been shown to have activity against lymphocytic PS-P-388 (P388) leukemia in mammals. A wide range of N-substituents and metallo complexes, and their preparation are given. Anti-tumor use is demonstrated against P388 leukemia in animals.

REFERENCES:
patent: 2858320 (1958-10-01), Woods et al.
Lavallee et al., Inorganic Chemistry, vol. 13, No. 8, 1974, pp. 2004-2008.
Lavallee, Inorganic Chemistry, vol. 16, No. 4, 1977, pp. 955-957.
Lavallee, Inorganic Chemistry, vol. 15, No. 3, 1976, pp, 691-694.
Ackerman et al., Inorganic Chem., vol. 18, No. 12, 1979, pp. 3358-3364.

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