Process of preparing enantiomerically pure 1,8-bridged 4-quinolo

Details Process of preparing enantiomerically pure 1,8-bridged 4-quinolo Process of preparing enantiomerically pure 1,8-bridged 4-quinolo

1989-02-23

1993-08-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

540547, 540559, 544344, C07D49806, C07D48706

Patent

active

052370607

ABSTRACT:
The invention relates to a process for the preparation of highly antibacterially active enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives of the formula (I) ##STR1## in which 1) a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## to form a compound of the formula ##STR4## followed by cyclization to form a compound of the formula ##STR5## and further cyclization to form a compound of the formula ##STR6## an finally reaction of the cyclized product with amines of the formula ##STR7##

REFERENCES:
patent: 4762831 (1988-08-01), Grohe et al.
patent: 4777253 (1988-10-01), Mitscher et al.
patent: 4859773 (1989-08-01), Grohe et al.

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