Pyridinyl compounds which are useful as angiotensin II antagonis

Details Pyridinyl compounds which are useful as angiotensin II antagonis Pyridinyl compounds which are useful as angiotensin II antagonis

1992-02-11

1993-08-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514349, 514350, 514352, 514354, 546276, 546297, 546310, 546312, 546304, 546256, 544315, 544319, 544333, C07D40112, A61K 3144

Patent

active

052369374

ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Rz, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. ##STR1##

REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4880804 (1989-11-01), Carini et al.
A. D. Shevchenko, et al., "Synthesis of some p-(aminomethyl)benzoic acid derivatives and their properties" Chem. Abstr. (1977), 86, 171.350u.
G. R. Proctor, et al., "Azabenzocycloheptenones. Part XIV. Cyclisation of Amino-acid Derivatives to Tetrahydro-1-benzazepin-5-ones and Tetrahydroquiolin-4-ones" J. Chem. Soc., Perkin Trans. I (1972), 1803-1808.

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