Oxadiazinone substituted indole and benzimidazole derivatives

Details Oxadiazinone substituted indole and benzimidazole derivatives Oxadiazinone substituted indole and benzimidazole derivatives

1992-05-26

1993-08-17

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 68, C07D41306, A61K 31535

Patent

active

052369161

ABSTRACT:
Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

REFERENCES:
J. H. Freeman et al., "1,2,4-Benzothiadiazine Dioxides and 3,4-Dihydro-3,4-Dihydro-1,2,4-Benzothiadiazine Dioxides", J. Org. Chem. 16, 815 (1951).
K. S. Atwal et al., "Substituted 1,4-Dihydropyrimidines, 3. Synthesis of Selectively Functionalized 2-Hetero-1,4-dihydropyrimidines", J. Org. Chem. 54, 25 (1989), pp. 5898-5907.

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