Synthetic pulmonary surfactant

Details Synthetic pulmonary surfactant Synthetic pulmonary surfactant

1988-10-26

1989-08-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530325, 530326, A61K 3702, C07K 708, C07K 710

Patent

active

048617563

ABSTRACT:
Certain polypeptide-phospholipid complexes consisting of the amphipathic, helical portion of human apo A and its analogs and a phospholipid are useful in the treatment of neonatal respiratory distress syndrome.

REFERENCES:
patent: 4312860 (1982-01-01), Clements
patent: 4338301 (1982-07-01), Tetsuro et al.
R. T. White et al., Nature, 317(26), 361 (1985).
A. Argiolas and J. J. Pisano, J. Biol. Chem., 260(3), 1437 (1985).
Chaffee and Greisheimer, Basic Physiology and Anatomy, J. P. Lippincott Co., New York, 1974, pp. 358-361.
J. B. West, ed., Physiological Basis of Medical Practice, 11th ed., Williams and Wilkins, Baltimore, 1985, pp. 586-592.

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