N3-alkyl-2',5'-0-silylated-3'-spiro-thymidine derivatives

Details N3-alkyl-2',5'-0-silylated-3'-spiro-thymidine derivatives N3-alkyl-2',5'-0-silylated-3'-spiro-thymidine derivatives

1992-09-03

1996-06-18

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

A61K 3170, C07H 19067

Patent

active

055279007

ABSTRACT:
Nucleoside analogs possessing anti-HIV activity and having a 3'-spiro moiety and blocking groups at the 2'- and 5'-positions. The preferred species is shown in the structure below: ##STR1## wherein R is alkyl.

REFERENCES:
Velasquez et al., J. Med. Chem. 36: 3230-3239, 1993.
"Enantiomeric synthesis of (+)-BCH-189 [(+)-. . . (2S,5R)-1-[2-(hydroxy-myl)-1,3-oxathiolan-5-y1]cytosine] from D-mannose and its anti-HIV activity," Chemical Abstracts, vol. 115, No. 21, pp. 1006, 1991, Abstr. No. 232751s.

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