Certain 5-halo-6,9.alpha.-epoxy-14-bromo(or chloro)-PGF.sub.1 co

Details Certain 5-halo-6,9.alpha.-epoxy-14-bromo(or chloro)-PGF.sub.1 co Certain 5-halo-6,9.alpha.-epoxy-14-bromo(or chloro)-PGF.sub.1 co

1977-09-02

1978-11-07

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

542426, 542429, 260308D, 26034673, C07D30793

Patent

active

041246012

ABSTRACT:
Prostaglandin E (PGE) - type derivatives and analogs having a 6-keto feature are disclosed, including processes for preparing them and the appropriate intermediates, said derivatives having pharmacological activity.
A typical 6-keto compound is 6-keto-PGE.sub.1, methyl ester, represented by the formula: ##STR1##

REFERENCES:
gandolfi et al., Il Farmaco, Ed. Sc., 27, 1125 (1972).
R. A. Johnson et al., Prostaglandins, 12, 915, (1976).
E. J. Corey et al., J. Am. Chem. Soc., 92, 397, (1970).
J. Fried et al., Proc. Natl. Acad. Sci. USA 74, 2199 (1977).

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