Hybrid human leukocyte interferons

Details Hybrid human leukocyte interferons Hybrid human leukocyte interferons

1981-09-25

1984-06-26

Wiseman, Thomas G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4351723, 435253, 435317, 435811, 435 68, 435 70, 435 91, C12N 1500, C12N 120, C12N 100, C07H 2104, C12P 2100, C12P 2102, C12P 1934

Patent

active

044567480

ABSTRACT:
Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.

REFERENCES:
patent: 4262090 (1981-04-01), Colby et al.
Derynck et al., Nature 285, 542, (1980).
Nagata et al., Nature 284, 316, (1980).
Taniguchi et al., Proc. Japan. Acad. 55, Ser. B, 464, (1979).
Nienhuis et al., New Eng. J. Med. 297, 1318, (1977).
Miozzari et al., Nature 277, 486, (1979).
Research Disclosure, Jul. 1979, pp. 351-352, 1351.
Itakura et al., Science 196, 1056, (1977).

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