Method of preparing prostaglandin B.sub.1 derivatives

Details Method of preparing prostaglandin B.sub.1 derivatives Method of preparing prostaglandin B.sub.1 derivatives

1979-04-02

1981-01-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562503, C07C17700

Patent

active

042451116

ABSTRACT:
An improved method for synthesizing and purifying PGB.sub.x, a mixture of lymers of prostaglandin B.sub.1. PGB.sub.x activity is assayed by measuring the minimum amount of PGB.sub.x required to restore complete phosphorylation ability to isolated rat liver mitochondria, first aged and degraded to the point where they exhibit less than 5% of the phosphorylating ability of normal mitochondria. A higher and more reproducible yield of PGB.sub.x of improved quality have been produced thereby.

REFERENCES:
patent: 4153808 (1979-05-01), Polis et al.
Polis, Fourth International Prostaglandin Conference, May 27, 1979.

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