Cephalosporins having (.alpha.-etherified oximino) acylamido gro

Details Cephalosporins having (.alpha.-etherified oximino) acylamido gro Cephalosporins having (.alpha.-etherified oximino) acylamido gro

1975-12-19

1978-03-14

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50146

Patent

active

040791785

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##STR1## WHERE R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range or gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
Gregson et al., Abstract of L, "Chemical Abstracts", vol. 77, p. 405, abst. no. 126,662a.
Cook et al., Abstract of M, "Chemical Abstracts", vol. 78, p. 525, abst. no. 58,444z.

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