Method of inhibiting carcinogenesis by treatment with dehydroepi

Details Method of inhibiting carcinogenesis by treatment with dehydroepi Method of inhibiting carcinogenesis by treatment with dehydroepi

1994-08-02

1996-06-18

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514 99, 514102, 514121, 514171, 514172, 514690, A61K 3156, A61K 31665, A61K 3166, A61K 3156, A61K 3158

Patent

active

055277896

ABSTRACT:
A method of combatting cancer in a subject comprising administering to said subject dehydroepiandrosterone (DHEA) or an analog thereof in an amount effective to combat cancer is disclosed in which heart failure induced by the DHEA or analog thereof is combatted by administering to the subject a ubiquinone, in an amount effective to combat heart failure induced by the DHEA or analog thereof.
A prefered DHEA analog for carrying out the invention is 16 alpha-fluoroepiandrosterone, and a preferred ubiquinone for carrying out the invention is Coenzyme Q.sub.10.

REFERENCES:
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patent: 5001119 (1991-03-01), Schwartz et al.
M. Abou-Gharbia et al., J. Pharm. Sci. 70, No. 10, 1154-1157 (1981).
K. Folkers et al., Proc. Natl. Acad. Sci. USA 87, 8931-8934 (1990).
S. Greenberg and W. Frishman, J. Clin. Pharmacol. 30, 596-608 (1990).
S. Mortensen et al., Int. J. Tiss. Reac. XII, No. 3, 155-162 (1990).
J. Nyce et al., Carcinogensis 5, No. 1, 57-62 (1984).
S. Schulz and J. Nyce, Cancer Research 51, 6563-6567 (1991).

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