Dislocation of cataractous lens by enzymatic zonulolysis

Details Dislocation of cataractous lens by enzymatic zonulolysis Dislocation of cataractous lens by enzymatic zonulolysis

1994-06-22

1996-06-18

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514912, A61K 3700

Patent

active

055277748

ABSTRACT:
This invention is for a method of treating cataracts in eyes by couching or dislocating of the cataractous lens. It includes the steps of introducing a zonulolysis-causing substance into the interior of the eye adjacent to the cataractous lens in sufficient quantity and strength to produce zonulolysis of the lens zonules normally holding the lens of the eye in place. The zonulolysis-causing substance is maintained in said eye adjacent the zonules until zonulolysis occurs and said lens moves into the inferior cavity of the eye. Alphachymotrypsin is one form of zonulolysis-causing substance. That substance may be introduced through a clear portion of the cornea into the anterior chamber of the eye without rupturing the lens capsule. A quantity of aqueous may be removed from the anterior chamber before introducing the zonulolysis-causing substance. That substance may also be introduced by injection of the substance through the pars plana into the vitreous behind the cataractous lens or by topical application in the presence of means to transport the substance to the lens zonules.

REFERENCES:
Kirby: The Early History of Cataract Surgery, SURGERY OF CATARACT 3-18, 1950.
Barraquer J.: Enzymatic Zonololysis, ACTA OPHTHALMOLOGICA 36:803-806, 1958.
Barraquer J.: Enzymatic Zonulolysis in Lens Extraction, ARCH OPHTHALMOL 66:6-11, 1961.
Sood N. N., Ratnaraj A.: Couching for Cataract, Hazards and Management, AM J OPTHALMOL 66:687-693, 1968.
Brandt F., Hennig A., Prasad L. N., Rai N. C., Upadhyay M. P.: Results of operative/couching of the lens (a study from Nepal), KLIN. MBL. AUGENHEILK 85:543-546, 1984.
Belyaev V. S., and Barachlov, V. I.: A Modern Experience with Couching for Catarcat, ANNALS OF OPTHALMOLOGY 14:742-745, 1982.
Chandler P. A.: Choice of Treatment in Dislocation of the Lens, ARCH OPHTHALMOL 71:765-786, 1964.
Grant W. M.: Chymotrypsin. Toxicology of the Eye, Springfield; Charles C. Thomas 1986; 235-239.
Article by Dr. Girard in Ocular Surgery News, Feb. 2, 1993.

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