Complexes of aescin, .beta.-sitosterol or cholesterol, and phosp

Details Complexes of aescin, .beta.-sitosterol or cholesterol, and phosp Complexes of aescin, .beta.-sitosterol or cholesterol, and phosp

1990-12-19

1992-06-02

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 33, 514182, 536 41, 536 5, 536117, A61K 31705, A61K 31575, A61K 31685

Patent

active

051186713

ABSTRACT:
Complexes formed between aescin, cholesterol or .beta.-sitosterol and phospholipids are described. The molar ratio of phospholipids to aescin/.beta.-sitosterol or cholesterol is from 0.5 to 2. The phospholipids are selected from the group of soy or egg lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phospatidylserine, phosphatidylethanolamine in which the acyl groups may be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids, for instance, pharmaceutical compositions and a method for producing an anti-inflammatory effect in an animal are also described.

REFERENCES:
patent: 4101652 (1978-07-01), Bonati
patent: 4624919 (1986-11-01), Kokusho et al.
Assa et al; Biochim. Biophys. Acta 307:83-91 (1973).
Elias et al; J. Histochem. Cytochem. 27(9):1247-1260 (1979).
Nakamura et al; Chem. Pharm. Bull. 29(6):1681-1688 (1981).
Yu et al; Chem.-Biol. Interactions 52:185-202 (1984).

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