Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1989-11-30
1992-06-02
Naff, David M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435184, C12N 500, C12N 999
Patent
active
051186241
ABSTRACT:
This invention relates to the inhibition of cell proliferation in mammalian host organisms. More particularly the invention relates to the utilization of selenodithiol compositions, particularly selenodiglutathione (GSSeSG) within a narrow concentration range, in which it is both effective as an inhibitor of cancer tumor cell proliferation in mammals, particularly in the prevention of neoplastic cell division in humans, while substantially non toxic outside this narrow range to the treated host organism. The invention also relates to a method for stimulating cellular proliferation at lower concentration of selenodiglutathione.
REFERENCES:
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Vernie et al., Elongation Factor 2 As the Target of the Reaction Product Between Glutathione (GSSeSG) in the Inhibiting of Amino Acid Incorporation In Vitro, Biochim. Biophys. Acta, 414, 1975, pp. 283-292.
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Kralick Francis A.
Orr Gregory N.
Parrish Wayne B.
Willett Darryl N.
Foster Frank H.
Meller Mike
Naff David M.
The Ohio State University
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