Method of screening purine nucleoside compounds or analogs for t

Details Method of screening purine nucleoside compounds or analogs for t Method of screening purine nucleoside compounds or analogs for t

1989-08-31

1992-06-02

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 29, C12Q 168, C12Q 106

Patent

active

051186012

ABSTRACT:
Methods for increasing extracellular concentrations of adenosine for the prophylactic or affirmative treatment of diseases of the immune, nervous, cardiac, and vascular systems involving administering to a patient purine nucleoside and purine nucleoside-related analogs which increase extracellular adenosine concentration, and methods for stabilizing mast cells by the suppression of mast cell activation using such compounds.

REFERENCES:
Henderson et al, "Relationships among purine nucleoside metabolism, adenosine triphosphate catabolism, and glycolysis in human erythrocytes", Can. J. Biochem, 57 (1979) 873-8.
Mann et al, "Release of adenosine and its metabolites from activated human leucocytes", Clinical Science 70 (1986) 461-68.
Matsumoto et al, "Adenine Nucleotide Degradation during Energy Depletion in Human Lymphoblasts", J. Biol. Chem. 254 (1979) 8956-62.
Iizasa et al, "Modulation of Adenine Nucleoside Excretion and Incorporation in Adenosine Deaminase Deficient Human Lymphoma Cells", Biochem. Biophys. Res. Comm., 121 (1984) 514-20.
Sheppard et al, "Cyclic AMP, Membrane Transport and Cell Division; I. Effects of Various Chemicals on Cyclic AMP Levels and Rate of Transport of Nucleosides, Hypoxanthine and Deoxyglucose in Several Lines of Cultured Cells", J. Cell. Physiol. 85 (1975) 163-72.

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