Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-08-14
1980-09-09
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546153, 546155, A61K 3147, C07D21556
Patent
active
042217970
ABSTRACT:
The compounds are amino- or cyano-bearing dihydroquinolines, which have either of the combinations of (a) 2-amino, 3-carboxylic and 4-oxo functions, or (b) 2-oxo, 3-cyano and 4-hydroxy functions, and may be optionally substituted at 1 or 2 of the 5, 6, 7 or 8 positions, eg 1-allyl-2-amino-1,4-dihydro-6,7-dimethoxy-4-oxo-quinoline-3-carboxylic acid ethyl ester, and 1-allyl 3-cyano-1,2-dihydro-4-hydroxy-6,7-dimethoxy-2-oxo-quinoline. The compounds are useful as pharmaceuticals.
REFERENCES:
patent: 4070468 (1978-01-01), Hardtmann et al.
patent: 4107310 (1978-08-01), Allais et al.
patent: 4123536 (1978-10-01), Connor et al.
Coutts et al., "J. Chem. Soc." (1962), pp. 2518-2521.
Coppola Gary M.
Hardtmann Goetz E.
Rizzo Nicholas S.
Sandoz Inc.
Sharkin Gerald D.
Vila Richard E.
Weinfeldt Frederick H.
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