Intermediate and process for the preparation of 7-acylindolin-2-

Details Intermediate and process for the preparation of 7-acylindolin-2- Intermediate and process for the preparation of 7-acylindolin-2-

1979-02-16

1980-09-09

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032616, C07D20934, C07D20908

Patent

active

042217164

ABSTRACT:
A novel process for the preparation of 7-acylindolin-2-ones of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or trifluoromethyl; R.sup.1 is lower alkyl, alkylphenyl, cycloalkyl, or aryl; and R.sup.2 is hydrogen, lower alkyl or benzyl is provided. The compounds are useful as intermediates in the preparation of 2-amino-3-acylphenylacetic acid compounds which possess pharmaceutical properties.

REFERENCES:
T. Sugasawa et al., JACS, 100:15, pp. 4842-4852 (1978).
E. Pratt et al., JOC, 29, pp. 1540-1543 (1964).
J. Powers, JOC, 31, pp. 2627-2631 (1966).
W. Lawson et al., JACS. 82, p. 5918 (1960).
V. W. Houlihan, Indoles, Part I, pp. 77, 115, 116. Wiley & Sons, NY (1972).

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