Homogeneous erythropoietin compositions and methods of using sam

Details Homogeneous erythropoietin compositions and methods of using sam Homogeneous erythropoietin compositions and methods of using sam

1992-07-31

1994-06-21

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 530380, 530397, A61K 3724, C07K 1514

Patent

active

053228375

ABSTRACT:
A method for purifying erythropoietin is described. The method comprises treating partially purifying erythropoietin by reverse phase high performance liquid chromatography to obtain homogeneous erythropoietin having a molecular weight of about 34,000 daltons on SDS PAGE and moving a single peak on reverse phase HPLC. The homogeneous erythropoietin protein preferably has a specific activity of at least 120,000 IU, more preferably at least 160,000 IU per absorbance unit at 280 nm.

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patent: 4568488 (1986-02-01), Lee-Huang
patent: 4677195 (1987-01-01), Hewick et al.
patent: 4703008 (1987-10-01), Lin
Miyake et al., J. Biol. Chem., 252, 5558-5564 (1977).

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