Saponin-based polyether polyols, pharmaceutical compositions and

Details Saponin-based polyether polyols, pharmaceutical compositions and Saponin-based polyether polyols, pharmaceutical compositions and

1983-11-04

1985-10-08

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 5, 536 6, 536 61, A61K 31705, C07J 1700

Patent

active

045460973

ABSTRACT:
Digitonin and digitonin-related saponins are derivatized by alkoxylation. The adducts have lower toxicity, higher solubility, and reduced ability to form insoluble complexes with cholesterol, as compared to the starting material. The adducts are particularly useful as solubilizing agents for lipophilic drugs and as mycoplasma suppressors in cell cultures.

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patent: 4230824 (1980-10-01), Nodelman
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patent: 4332936 (1982-06-01), Nodelman
"The Merck Index", 9th Ed., 1976, 3137, p. 417.

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