Fluorescent phospholipid analogs and fatty acid derivatives

Details Fluorescent phospholipid analogs and fatty acid derivatives Fluorescent phospholipid analogs and fatty acid derivatives

1993-02-16

1994-06-21

Bhat, Nina

Chemistry: analytical and immunological testing

Lipids, triglycerides, cholesterol, or lipoproteins

436 55, 436 56, 436128, 436172, 560 52, 560 53, 560 54, 560101, G01N 3392, G01N 2176, C07C 6976, C07C 6995

Patent

active

053227948

ABSTRACT:
Fluorescence probes are described comprising coronene fluorophores chemically attached to lipids or membrane-mimetic molecules via hydrocarbon spacers of defined length. Also described is a method for determining lipid packing and dynamics in membranes, a method for estimating hydrodynamic properties of macromolecules and macromolecular complexes, and a method for measuring changes in Ca.sup.+2 concentrations in or near membranes.

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