Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-09-11
2000-06-06
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514254, 514290, 544 60, 546 93, A61K 3154, A61K 31445, C07D40114, C07D41714
Patent
active
060719079
ABSTRACT:
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
REFERENCES:
patent: 4355036 (1982-10-01), Villani
patent: 4454143 (1984-06-01), Villiani
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5393890 (1995-02-01), Syoji et al.
patent: 5661152 (1997-08-01), Bishop et al.
patent: 5672611 (1997-09-01), Doll et al.
patent: 5684013 (1997-11-01), Afonso et al.
patent: 5696121 (1997-12-01), Bishop et al.
patent: 5700806 (1997-12-01), Doll et al.
patent: 5703090 (1997-12-01), Afonso et al.
patent: 5712280 (1998-01-01), Doll et al.
patent: 5714609 (1998-02-01), Doll et al.
patent: 5719148 (1998-02-01), Bishop et al.
patent: 5721236 (1998-02-01), Bishop et al.
patent: 5728703 (1998-03-01), Bishop et al.
patent: 5874442 (1999-02-01), Doll
Bishop, W. Robert, et al., Novel Tricycle Inhibitors of Farnesyl Protein Transferase, The Journal of Biochemical Chemistry, vol. 270, No. 15, pp. 30611-30618 (1995).
Kohl, Nancy E., et al., Selective Inhibition of Ras-Dependent Transformation By A Farnesyltransferase Inhibitor, Science, vol. 260, pp. 1834-1837.
Njoroge, F. George, et al., Novel Tricycle Aminoacetyl and sulfonamide inhibitors of Ras Farneysl Protein Transferase, Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 24, pp. 2977-2982 (1996).
Wong, J.K., et al., Bioorganic & Medicinal Chemistry Letters, vol. 3, No. 6, pp. 1073-1078 (1993).
Liu Yi-Tsung
Njoroge F. George
Taveras Arthur G.
Huang Evelyn Mei
Jeanette Henry C.
Majka Joseph T.
Schering Corporation
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