Spiro[pyrrolidine-2,3'-oxindole] compounds and methods of use

Details Spiro[pyrrolidine-2,3'-oxindole] compounds and methods of use Spiro[pyrrolidine-2,3'-oxindole] compounds and methods of use

1998-09-08

2000-09-05

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548411, 548147, 548159, 548179, C07D20996, C07D48710, C07D51310

Patent

active

061145408

ABSTRACT:
The invention provides spiro[pyrrolidine-2,3'-oxindole] compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, .alpha.-amino acids, and dipolarophiles (e.g., trans-chalcones, acrylate esters, or vinyl oxindoles).

REFERENCES:
patent: 5958792 (1999-09-01), Desai et al.
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Fokas et al., "Solution Phase Synthesis of a Spiro[pyrrolidine-2,3'-oxindole] Library via a Three Component 1,3-Dipolar Cycloaddition Reaction", Tetrahedron Letters, 39, pp. 2235-2238, 1998.
Powers et al., "Automated Parallel Synthesis of Chalcone-Based Screening Libraries", Tetrahedron, 54 pp. 4085-4096, 1998.

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