Method of preventing NMDA receptor complex-mediated neuronal dam

Details Method of preventing NMDA receptor complex-mediated neuronal dam Method of preventing NMDA receptor complex-mediated neuronal dam

1998-08-21

2000-06-06

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 12, 514 21, 514410, 514742, A61K 3828, A61K 3800, A61K 3140

Patent

active

060718765

ABSTRACT:
Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.

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