Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1999-05-19
2000-06-06
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514913, A61K 3800
Patent
active
060718757
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Glaucoma is currently treated using one or more of three strategies to lower the elevated intraocular pressure associated with the disease: with pharmaceuticals (such as beta-blockers, carbonic anhydrase inhibitors, and miotics), with laser trabeculoplasty, and/or with glaucoma filtration surgery. All of these therapies indirectly lower intraocular pressure but do not address the underlying disease process occurring in the trabecular meshwork.
Transforming growth factor alpha (TGF.alpha.) is a relative of epidermal growth factor (EGF) and like EGF, it exerts its effects on cells through binding to the EGF receptor. The precise physiological roll of TGF.alpha. is still not clear, although it appears to be important in eye and hair follicle development and may play a role in both the immune system and in wound healing. See Kumar, et al., Cell Biology International, "Transforming Growth Factor Alpha," 19:5, 373-388, 1995.
SUMMARY OF THE INVENTION
The present invention is directed to methods for treating persons suffering from glaucoma or ocular hypertension through the administration of compositions containing TGF.alpha..
DESCRIPTION OF PREFERRED EMBODIMENTS
Surprisingly, it has been discovered that there is a decrease in TGF.alpha. mRNA expression in trabecular meshwork (TM) cells treated with glucocorticoids and in TM cells derived from glaucomatous donors. It has been found that TGF.alpha. is an important regulator of TM cell function and, therefore, the lack thereof is believed to be responsible for altered TM cell function leading to the elevated intraocular pressure associated with glaucoma and glucocorticoid-induced ocular hypertension. It is believed that the administration of TGF.alpha. to an ocular hypertensive eye will restore normal TM cell function and thereby normalize trabecular outflow resulting in a lowering of intraocular pressure. This treatment is advantageous over prior methods because it interferes with or even prevents the ongoing disease process rather than simply treating the symptoms, particularly elevated intraocular pressure.
As will be appreciated by those skilled in the art, TGF.alpha. may be delivered topically, via intraocular (e.g., intracameral) injection or retrograde injection into episcleral veins (see U.S. Pat. No. 5,364,374), through erodible solid ocular inserts, iontophoresis (see Sarraf, et al., Journal of Ocular Pharmacology, "The Role of Iontophoresis in Ocular Drug Delivery," 10:1, 69-81, 1994), or by electroporation.
For topical ophthalmic delivery, TGF.alpha. may be combined with ophthalmologically acceptable preservatives, surfactants, viscosity enhancers, penetration enhancers, buffers, sodium chloride, and water to form an aqueous, sterile ophthalmic suspension or solution. Ophthalmic solution formulations may be prepared by dissolving the compound in a physiologically acceptable isotonic aqueous buffer. Further, the ophthalmic solution may include an ophthalmologically acceptable surfactant to assist in dissolving the compound. Furthermore, the ophthalmic solution may contain a thickener such as hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylcellulose, polyvinylpyrrolidone, or the like, to improve the retention of the formulation in the conjunctival sac. In order to prepare sterile ophthalmic ointment formulations, the active ingredient is combined with a preservative in an appropriate vehicle, such as, mineral oil, liquid lanolin, or white petrolatum. Sterile ophthalmic gel formulations may be prepared by suspending the active ingredient in a hydrophilic base prepared from the combination of, for example, carbopol-940, or the like, according to the published formulations for analogous ophthalmic preparations; preservatives and tonicity agents can be incorporated.
Whether TGF.alpha. is delivered via topical administration or by another previously mentioned route, the pH of the formulation should be about 5-9. The ophthalmic compositions are formulated to provide for an intraocular concentr
REFERENCES:
patent: 5364374 (1994-11-01), Morrison et al.
Smyth, et al., The Effects of Transferrin Receptor Antibody, Transferrin eptor Antibody Bound to Pseudomonas Exotoxin and Transforming Growth Factor-.alpha. Bound to Pseudomonas Exotoxin on Human Tenon's Capsule Fibroblast Proliferation, Journal of Ocular Pharmacology, vol. 8(1):83-90, 1992.
Sarraf, et al., "The Role of Iontophoresis in Ocular Drug Delivery," Journal of Ocular Pharmacology, vol. 10(1):69-81, 1994.
Kumar, et al., "Transforming Growth Factor Alpha," Cell Biology International, vol. 19(5):373-388, 1995.
Clark Abbot F.
Wordinger Robert J.
Alcon Laboratories Inc.
Fay Zohreh
University of North Texas Health Science Center at Fort Worth
Yeager Sally
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