Synthetic polypeptides and antibodies related to epstein-barr vi

Details Synthetic polypeptides and antibodies related to epstein-barr vi Synthetic polypeptides and antibodies related to epstein-barr vi

1984-08-08

1987-03-31

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, C07K 708

Patent

active

046544194

ABSTRACT:
Antigens, immunogens, inocula, antibodies, diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EBNA) are disclosed. Each of the compounds, compositions, methods or systems contains a synthetic, random copolymer polypeptide having about 6 to about 40 residues, or an antibody containing site that immunoreacts with such a polypeptide. The polypeptide includes the five amino acid residue sequence -Gly-R.sup.1 -Gly-R.sup.2 -Gly-, wherein R.sup.1 and R.sup.2 are the same or different amino acid residues selected from the group consisting of Ala, Asn, Arg, Gly, Leu, Pro, Ser, and Thr, with the provision that R.sup.1 and R.sup.2 are not both Gly. The polypeptide contains at least 25 mole percent Gly residues, and when linked to a carrier and introduced in an effective amount into a mammalian host is capable of inducing production of antibodies that immunoreact with EBNA.

REFERENCES:
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patent: 4224306 (1980-09-01), Zichis
patent: 4407965 (1983-10-01), Yanaihara
patent: 4423034 (1983-12-01), Nakagawa et al.
patent: 4474757 (1984-10-01), Arnon et al.
patent: 4474886 (1984-10-01), Willard
Journal of Immunological Methods 67, (1984) pp. 145-156.
Proceedings of the Nat'l Acad. Sciences (1983) 80, pp. 5665-5669.
Proceedings of the Nat'l Acad. Science (1984) 81, pp. 4652-4656.

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