Synthesis of sulfurized oligonucleotides

Details Synthesis of sulfurized oligonucleotides Synthesis of sulfurized oligonucleotides

1997-10-15

2000-09-05

Crane, L. Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2533, 568 22, C07H 2100, C07H 2102, C07H 2104

Patent

active

06114519&

ABSTRACT:
Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.

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