Synthetic analogs of mevinolin

Details Synthetic analogs of mevinolin Synthetic analogs of mevinolin

1985-11-04

1987-03-31

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549292, 514824, 560 56, 562466, C07D30930, A61K 31365

Patent

active

046543635

ABSTRACT:
Certain 6-(substituted-naphthyl)hydrocarbyl-4-hydroxytetrahydropyran-2-ones are unexpectedly potent in the treatment of familial hypercholesterolemia, hyperlipemia and atherosclerosis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase).

REFERENCES:
patent: 4248889 (1981-03-01), Oka et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mistui et al.
patent: 4375475 (1983-03-01), Willard et al.
Willard et al; CA 98:17922x (1983).

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