Method for treating diarrhea with benzothiophene derivatives

Details Method for treating diarrhea with benzothiophene derivatives Method for treating diarrhea with benzothiophene derivatives

1985-06-28

1987-03-31

Jiles, Henry H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514443, 546274, 548525, 549 51, 549 57, A61K 3138, A61K 3141, A61K 31445

Patent

active

046543520

ABSTRACT:
Compounds of the formula: ##STR1## and pharmaceutically-acceptable acid addition salts thereof, wherein R.sup.1 is at the 3 or 4 position and is phenyl or phenyl substituted by halo, (C.sub.1 -C.sub.4)alkoxy, or (C.sub.2 -C.sub.5)alkoxycarbonyl; R.sup.2 is at the 2 or 7 position and is a group of the formula X(CH.sub.2).sub.n NR.sup.3 R.sup.4 where X is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; n is 1, 2, 3 or 4; and each of R.sup.3 and R.sup.4 is hydrogen or (C.sub.1 -C.sub.4)alkyl, or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a 1-pyrrolidinyl or piperidino group; Y is hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy or (C.sub.2 -C.sub.5)-alkoxycarbonyl at the 4, 5, 6 or 7 position; and wherein R.sup.2 is at the 2-position, R.sup.1 is at the 3- or 4-position, or alternatively when R.sup.2 is at the 7-position, R.sup.1 is at the 3-position; are useful for the treatment of diarrhea in humans and animals.

REFERENCES:
patent: 3598839 (1971-08-01), Kaltenbronn
patent: 3944672 (1976-03-01), Steinman
patent: 4018893 (1977-04-01), Steinman
patent: 4137414 (1979-01-01), Kulka

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