Oral absorption enhancement of carboxylic acid pharmaceuticals u

Details Oral absorption enhancement of carboxylic acid pharmaceuticals u Oral absorption enhancement of carboxylic acid pharmaceuticals u

1984-08-23

1987-03-31

Clarke, Vera C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514161, 514195, 514202, 514203, 514204, 514206, 514207, 514263, 514314, 514333, 514397, 514415, 514461, 514467, 540221, 540225, 540226, 540227, 540228, 540304, 540314, 540347, 549229, A61K 31625, A61K 31665, A61K 31335, A61K 31425, A61K 31545, C07D49932, C07D50144, C07D31724

Patent

active

046543317

ABSTRACT:
The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: ##STR1## wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic acid functionality, enhances oral absorption of the pharmaceutical. This effect is applicable to a broad range of pharmaceutically active substances, including antibiotics, and antihypertensives as well as other classes of therapeutic agents.

REFERENCES:
patent: 4342693 (1982-08-01), Sakamoto et al.
patent: 4389408 (1983-06-01), Sakamoto et al.
patent: 4479947 (1984-10-01), Christensen

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