Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-03-24
2000-09-05
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514221, 514284, 514285, 514288, 514289, 514323, 514923, A61K 3148
Patent
active
06114326&
ABSTRACT:
The present invention provides for the use of cabergoline and other agents for the treatment of restless legs syndrome (RLS).
REFERENCES:
patent: 4526892 (1985-07-01), Salvati et al.
patent: 5496836 (1996-03-01), Di Rocco et al.
JE Ahlskog, et al., "Adjunctive Cabergoline Therapy of Parkinson's Disease: Comparison with Placebo and Assessment of Dose Response and Duration of Effect," Clin. Neuropharmacol, 1996; 19:202-212.
S Akpinar, "Restless Legs Syndrome Treatment with Dopaminergic Drugs," Clinical Neuropharmacology, 1987; 10:69-79.
RP Allen, "Augmentation of the Restless Legs Syndrome with Carbidopa/Levodopa," Sleep, 1996; 19(3):205-13.
Anonymous, " Carbergolin: Neue Horizonte in der Therapie des Morbus Parkinson," Nervenarzt (1998 Sep.) 69 (Suppl Neue Horiz) 1-8, XP002116346.
Anonymous, "Cabergoline: New Horizons in Parkinson's Disease Treatment,"--Translated version of XP0021116346, pp. 1-17 (1998).
Atlas Task Force of the American Sleep Disorders Association, Recording and Scoring Leg Movements, Sleep, 1993; 16:748-759.
PM Becker, AO Jamieson, WD Brown, "Dopaminergic Agents in Restless Legs Syndrome and Periodic Limb Movements in Sleep: Response and Complications of Extended Treatment in 49 Cases," Sleep, 1993; 16:713-716.
D Boghen, et al., "The Treatment of Restless legs Syndrome with Clonazepam: A Prospective Controlled Study," Can J Neurol Sci, 1986; 13:245-247.
DB Boivin, D Lorrain, J Montplaisir, "Effects of Bromocriptine on Periodic Limb Movements in Human Narcolepsy," Neurology 1993; 43:2134-2136.
B Bornstein, "Restless Legs," Psychiat Neurol, 1961; 141:165-201.1.
C Brodeur, J Montplaisir, R Marinier, "Treatment of RLS and PMS with L-dopa: A Double-Blind Controlled Study," Neurology; 35:1845-1848. (1988).
V Collado-Seidel, et al., A Controlled Study of Additional sr-L-dopa in L-dopa-Responsive Restless Legs Syndrome with Late-Night Symptoms,Neurology, 1999, 52:285-290.
N Callaghan, "Restless Legs Syndrome in Uremic Neuropathy," Neurology, 1966, 16:359-361.
RM Coleman, "Periodic Movements in Sleep (Nocturnal Myoclonus) and Restless Legs Syndrome." In: Guilleminault C, (ed) Sleeping and Walking Disorders: Indications and Techniques, 1982, Menlo Park: Addison Wesley; 265-295.
CJ Earley, RP Allen, "Pergolide and Carbidopa/Levodopa Treatment of the Restless Legs Syndrome and Periodic Leg Movements in Sleep in a Consecutive Series of Patients," Sleep, 1996; 19(10):801-10.
KA Ekbom, "Restless Legs," Acta Medica Scandinavica, 1945 ; suppl. 158: 1-123.
KA Ekbom, "Restless Legs Syndrome," Neurology, 1960; 10:868-873.
RG Fariello, "Pharmacodynamic and Pharmacokinetic Features of Carbergoline," Drugs, 1997, 55:S2, 10-16.
A Feigen, "Restless Legs Syndrome," JAMA, 1995; 274 (15) 1191-2.
B Frankel, "Restless Legs Syndrome," JAMA, 1974; 230:1302-1303.
C Gorman, et al., "Symptoms of Restless Legs," Arch Intern Med, 1965; 115:155-60.
C Guilleminault, M Cetel, P Philip, "Dopaminergic Treatment of Restless Legs and Rebound Phenomenon," Neurology, 1993; 43(2):445.
D Harriman, et al., "Ekbom's Syndrome and Burning Paraesthesiae," Brain, 1970; 93:393-406.
EM Heiman, et al., "Lithium-Aggravated Nocturnal Myoclonus and Restless Legs Syndrome [letter]," American Journal of Psychiatry, 1986; 143:1191-1192.
F Heinze, et al., "Restless Legs and Orthostatic Hypotension in Primary Amyloidosis," Arch Neurol, 1967; 16:497-500.
W Hening, et al., "The Cortical Premovement Potentials of RLS Jerks," Sleep Res, 1991; 20:255.
WA Hening, et. al., "Dyskinesias While Awake and Periodic Movements in Sleep in Restless Legs Syndrome: Treatment with Opioids," Neurology; 1986; 36:1363-1366.
S Iannaccone, et al., "Evidence of Peripheral Axonal Neuropathy in Primary Restless Legs Syndrome," Movement Disorders, 1995; 10:2-9.
PW Kaplan, RP Allen, DW Suchholz, JK Walters, "A Double-Blind, Placebo Controlled Study of the Treatment of Periodic Limb Movements in Sleep Using Carbidopa/Levodopa and Propoxyphene," Sleep, 1993; 16:717-723.
S Kotagal, et al., "Nocturnal Myoclonus--A Sleep Disturbance in Children with Leukemia," Annals of Neurology, 1984; 16:392.
C Kramer, M Kerkjarto, B Leplow, EO Krasemann, "LebensqualitatsmeSsungen im wochentlich erhobenen Verlauf bei Herzinfarktpatienten," Psychother Psychosom Med Psychol, 1990; 40:409-416.
E Lugaresi, et al., "Nocturnal Myoclonus and Restless Legs Syndrome," In: S Fahn et al. (eds), Advances in Neurology, 1986, vol. 43: Myoclonus, New York: Raven Press; 295-307.
P Martinelli, et al., "Nocturnal Myoclonus, Restless Legs Syndrome, and Abnormal Electrophysiological Findings," Ann Neurol, 1987; 21:515.
WB Matthews, "Iron Deficiency and Restless Legs," Br Med J, 1976; 1-898.
M Miyagi, et al., "Dopamine Receptor Affinities in vitro and Stereotypic Activities in Vivo of Cabergoline in Rats," Biol. Pharm. Bull., 1996; 19L 1210-1213.
H Moldofsky, et al., "Sleep-Related Myoclonus in Rheumatic Pain Modulation Disorder (Fibrositis Syndrome) and in Excessive Daytime Somnolence," Psychosomatic Medicine, 1984; 46:145-151.
J Montplaisir, et al., "Familial Restless Legs with Periodic Movements in Sleep:Electrophysiologic, Biochemical, and Pharmacological Study," Neurology, 1985; 35:130-134.
J Montplaisir, et. al., "Restless Legs Syndrome and Periodic Movements in Sleep: Physiopathology and Treatment with L-dopa," Clinical Neuropharmacology, 1986; 9:456-463.
SS Mosko, et al., "Somatosensory and Brainstem Auditory Evoked Responses in Sleep-related Periodic Leg Movements," Sleep, 1986; 9:399-404.
W Ondo, "Ropinirole for Restless Legs Syndrome," Movement Disorder; 14:138-140 (1999).
G Reynolds, et al., "Restless Leg Syndrome and Rheumatoid Arthritis," British medical Journal, 1986; 292:659-660.
UK Rinne, et al: "Cabergoline in the Treatment of Early Parkinson's Disease: Results of the First Year of Treatment in a Double-Blind Comparison of Cabergoline and Levodopa," Neurology, 1997, 48/2 (363-368). XP002116347.
E Ruiz-Primo, Is Nocturnal Myoclonus a Common Sleep Disturbance in Children with Leukaemia, Dev Med Child Neurol, 1987; 29:833.
F Salvi, et al., "Restless Legs Syndrome and Nocturnal Myoclonus: Initial Clinical Manifestation of Familial Amyloid Polyneuropathy," J Neurol Neurosurg Psychiatry, 1990; 53:522-525.
R Sandyk, et al., "L-Dopa in Uremic Patients with the Restless Legs Syndrome," Int J Neurosci, 1987; 35:233-235.
MH Silber, JW Shepard, Jr., JA Wisbey, "Pergolide in the Management of Restless Legs Syndrome: An Extended Study," Sleep, 1997; 20(10): 878-82.
JD Spillane, "Restless Legs Syndrome in Chronic Pulmonary Diseases," Br Med J, 1970; 4:796-798.
K Stiasny, et al., "Treatment of Restless Leg Syndrome (RLS)with Cabergoline" ENS, Nice Abstract, 1988.
MJ Thorpy, Chairman, Diagnostic Classification Steering Committee in International Classification of Sleep Disorders: Diagnostic and Coding Manual, 1990, American Sleep Disorders Association.
C Trenkwalder, et al., "L-Dopa in Uremic and Idiopathic Restless Legs Syndrome:A Double-Blind, Crossover Trial," Sleep, 1995; 18:681-688.
PT Trzepacz, et. al., "Response to Opioids in Three Patients with Restless Legs Syndrome," Ann J Psychiatry, 1984; 141:993-995.
C Von Scheele, "Levodopa in Restless Legs," Lancet, 1986; 2:426-427.
C Von Scheele, V Kempi, Long-Term Effect of Dopaminergic Drugs in Restless Legs. A 2-Year Follow-up, Arch Neurol, 1990; 47:1223-1224.
SL Walker, A Fine, MH Kryger, "L-Dopa/Carbidopa for Nocturnal Movement in Uremia," Sleep, 1996; 19:213-218.
AS Walters, et al., "A Double-Blind Randomized Crossover Trial of Bromocriptine and Placebo in Restless Leg Syndrome," Ann Neurol, 1988; 24:455-458.
AS Walters, "Toward a Better Definition of the Restless Legs Syndrome," The International Restless Legs Syndrome Study Group., Mov Disord, 1995; 10(5):634-42.
JC Ware, et al., "Nocturnal Myoclonus and Tricyclic Antidepressants," Sleep Research, 1984; 13:72.
S Watanabe, et al., "Periodic Legs Movements During Either Epidural or Spinal Anesthesia in an Elderly Man without Sleep-related (Nocturnal) Myoclonus," Sleep, 1990; 13:262-266.
LR Wechsler, et al., "Periodic Leg Movements of Sleep (Nocturnal Myoclonus): An Electrophysiologic
Krass Frederick
Pharmacia & Upjohn Company
Wootton Thomas A.
LandOfFree
Use of cabergoline in the treatment of restless legs syndrome does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of cabergoline in the treatment of restless legs syndrome, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of cabergoline in the treatment of restless legs syndrome will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2212314