Methods for inhibiting the advanced glycosylation of proteins

Details Methods for inhibiting the advanced glycosylation of proteins Methods for inhibiting the advanced glycosylation of proteins

1998-12-17

2000-09-05

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142378, 5142385, 514514, 514331, 514399, 514561, 514531, A01N 4346

Patent

active

061143235

ABSTRACT:
The present invention relates to methods for inhibiting protein aging. Accordingly, methods are disclosed for treating an animal to inhibit the formation of advanced glycosylation end products of target proteins with the animal by adminstering a pharmaceutical composition comprising an agent capable of reacting with the carbonyl moiety of the early glycosylation product, whereby the subsequent cross-linking of the early glycosylation product is inhibited. Agents of the present invention comprise aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.

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