Method of detection for a polynucleotide encoding chemokine expr

Details Method of detection for a polynucleotide encoding chemokine expr Method of detection for a polynucleotide encoding chemokine expr

1998-12-01

2000-06-06

Mertz, Prema

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 235, 536 243, 536 2431, 530351, 435 695, 435 712, 435325, 435471, 4352523, 4353201, C12Q 168, C07K 1452, C12N 1519

Patent

active

060717017

ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization robes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

REFERENCES:
Vilcek, Jan et al., Immunology of Cytokines The Cytokine Handbook Academic Press, Copyright 1991, Chapter 1, pp. 1-17.
Shaw, Alan R., "Molecular Biology of Cytokines" The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 2, pp. 20-46.
Banchereau, Jacques, Interleukin-4" The Cytokine Handbook, Academic Press, Copyright 1991, Chapter 6, pp. 120-148.
Schall, Thomas J., "The Chemokines" The Cytokine Handbook, Academic Press, 1994, Sep. 19-20, Second Edition, pp. 180-272.
Uhlmann et al., "Antisense Oligonucleotides: a New Therapeutic Principle" Chemical Reviews 90(4):554-584 (1990).
Cotten et al., "Ribozyme Mediated Destruction of RNA in vivo" The EMBO Journal 8(12):3861-3866 (1989).
Ledley, F.D., "Clinical Consideration in the Design of Protocols for Somatic Gene Therapy" Human Gene Therapy 2:77-82 (1991).
Anderson, W.F., "Prospects for Human Gene Therapy" Science 226:401-409 (1984).
Opdenakker et al., "The Human MCP-3 Gene (SCYA7): Cloning, Sequence Analysis, and Assignment to the C--C Chemokine Gene Cluster on Chromosome 17q11.2-q12" Genomics 21:403-408 (1994).
Diamond et al., "Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing" Journal of Biol. Chem. 268(20):15185-15192 (1993).
Derynck et al. (1990) Biochemistry vol. 29, pp. 10225-10233.

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