Beta-lactam compounds, preparation and use

Details Beta-lactam compounds, preparation and use Beta-lactam compounds, preparation and use

1978-07-03

1979-03-20

Rush, Raymond V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260307DB, 260307FA, 424246, 424271, C07D49804, A61K 3142

Patent

active

041454308

ABSTRACT:
The compounds of the formula (I): ##STR1## wherein X represents a moiety of the sub-formula (a) or (b): ##STR2## HAVE BEEN FOUND TO BE .beta.-LACTAMASE INHIBITORS WHICH MAY BE USED IN PHARMACEUTICAL COMPOSITIONS TO ENHANCE THE EFFECTIVENESS OF PENICILLINS OR CEPHALOSPORINS. The diene of the formula (I) may be produced by the decarboxylation of clavulanic acid or a derivative thereof and the monoene of the formula (I) may be produced by the 1,4 addition of hydrogen to the diene of the formula (I). The diene is thus also useful as a chemical intermediate and other such uses are demonstrated.

REFERENCES:
patent: 4093626 (1978-06-01), Hunt

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