Thienopyridine substituted cephalosporins

Details Thienopyridine substituted cephalosporins Thienopyridine substituted cephalosporins

1976-12-29

1979-03-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602391, 546114, 546 80, 424271, 544 25, 544 27, 544 28, A61K 31545, C07D50136

Patent

active

041454189

ABSTRACT:
Thienopyridine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen, an alkyl, an aryl, an aralkyl or a halogen; R.sup.1 and R.sup.2 may, taken together, represent an alkylene group; X is hydrogen or an alkyl; Y is oxygen or sulfur; Z is phenyl which may optionally be substituted; R.sup.3 is hydrogen or an alkoxy; and R is a group of the formula: ##STR2## or of the formula: ##STR3## (wherein R.sup.4 is hydrogen, an acyloxy or a nucleophilic compound residue) or a pharmaceutically acceptable salt thereof are found to have activity against a broad spectrum of gram-positive and gram-negative bacteria, particularly against bacteria of the genus Pseudomonas .

REFERENCES:
patent: 3134774 (1964-05-01), Chow et al.
patent: 3487074 (1969-12-01), Sheehan
patent: 4041161 (1977-08-01), Kocsis et al.
patent: 4061748 (1977-12-01), Yamada et al.

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