Pancreatin micropellets prepared with polyethylene glycol 4000,

Details Pancreatin micropellets prepared with polyethylene glycol 4000, Pancreatin micropellets prepared with polyethylene glycol 4000,

1993-08-19

1995-01-03

Naff, David M.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Multienzyme complexes or mixtures of enzymes

424408, 435175, 435177, 435180, 435182, A61K 3762, A01N 2534, C12N 1108, C12N 1118

Patent

active

053784626

ABSTRACT:
Pancreatin-containing micropellet cores which can be coated with a gastric juice-resistant film are prepared by extruding a mixture containing pancreatin, polyethylene glycol 4000 and a lower alcohol such as propan-2-ol to produce extrudates which break by themselves into fragments, rounding the fragments with the addition of highly liquid paraffin and drying. Propan-2-ol may be present with the paraffin during rounding. The micropellet cores contain 65-85% pancreatin, and have a bulk density of 0.6 g/ml to 0.85 g/ml, a spherical to ellipsoidal shape with a minor axis in the range of 0.7-1.4 mm and a particle size distribution in which at least 80% of the micropellet cores have a minor axis to major axis ratio in the range from 1:1 to 1:2.

REFERENCES:
patent: 4079125 (1978-03-01), Sipos
patent: 4280971 (1981-07-01), Wischniewski et al.
patent: 5068110 (1991-11-01), Fawzi et al.
patent: 5219572 (1993-06-01), Sivaramakrishnan et al.
patent: 5225202 (1993-07-01), Hodges et al.
Derwent Abstract of JP 4-187,085.

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