Interferon sensitive recombinant poxvirus vaccine

Details Interferon sensitive recombinant poxvirus vaccine Interferon sensitive recombinant poxvirus vaccine

1991-12-16

1995-01-03

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4352351, 435236, 4242321, 935 32, 935 65, A61K 39275, A61K 39285, C12N 701

Patent

active

053784570

ABSTRACT:
What is described is a recombinant poxvirus, such as vaccinia virus, having enhanced sensitivity to interferon. In one embodiment, the recombinant poxvirus has an open reading frame conferring resistance to interferon deleted therefrom. In another embodiment, the recombinant poxvirus is modified to disrupt K3L gene expression. What is also described is a vaccine containing the recombinant poxvirus having enhanced sensitivity to interferon so that the vaccine has an increased level of safety compared to known recombinant poxvirus vaccines.

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