Diaza-spiro[3,5] nonane derivatives

Textiles: spinning – twisting – and twining

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 16, A61K 3144, C07D22120

Patent

active

061135275

ABSTRACT:
The invention relates to compounds of the general formula ##STR1## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;

REFERENCES:
patent: 5986097 (1999-11-01), Palermo et al.
Manhas et al., "Studies on Lactams-XII", Tetrahedron, vol. 25, No. 18, pp. 4421-4426 (1969).
Reinscheid et al., "Structures that Delineate Orphanin FQ and Dynorphin A Pharmacological Selectives", Journal of Biological Chemistry, vol. 273, No. 3, pp. 1490-1495 (1998).
Julius, Nature 377:476 (1995).
Meunier, Eur. J. Pharmacol., 340: 1-15 (1997).
Henderson et al., Trends Pharmacol. Sci., 18:293-300 (1997).
Mogil et al., Neuroscience, 75:333-337 (1996).
Vanderah et al., Eur. J. Pain, 2:267-280 (1998).
Jenck et al., Proc. Natl. Acad. Sci., USA, 94:14854-14858 (1997).
Pomonis et al., Neuroreport, 8:369-371 (1996).
Manabe et al., Nature, 394:577-581 (1998).
Peruso et al. J. Neuroimmmuno, 81:184-192 (1998).
Porro et al., Prog. Clin. Biol. Res. 397:315-325 (1998).
Benzow et al., Febs Lett. 347:284-288 (1994).
Cheng et al., Biochem. Pharmacol., 22:3099-3108 (1973).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diaza-spiro[3,5] nonane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaza-spiro[3,5] nonane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaza-spiro[3,5] nonane derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2206973

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.