Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-02-27
1993-02-23
Ramsuer, Robert W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
544165, C12P 1714
Patent
active
051889501
ABSTRACT:
Novel dipeptide isosteres are the biotransformed products after incubation with rat liver slices. They inhibit HIV protease, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts (when appropriate), pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
REFERENCES:
patent: 4537989 (1985-08-01), Ono et al.
patent: 4661473 (1984-03-01), Boger
patent: 4758563 (1988-07-01), Grous et al.
Evans, B. E. et al., "A Sterocontrolled Synthesis . . . " Proc. Am. Pept. Symp., 9, 743 (1985) (Evans II).
Luly, J. R. et al., "A Synthesis of Protected Aminoalkyl Epoxides," J. Org. Chem. 52, 1487 (1987).
ASM News, vol. 56, No. 7 (Jul., 1990) at 368.
Crawford, S. et al., "A Deletion Mutant in . . . pol . . . Blocks Proteolytic Processing . . . ," J. Virol. 53, 899 (1985).
Power, M. D. et al., "Nucleotide Sequence of SRV-1 . . . ," Science 231, 1567 (1986).
Azri, S. et al., In Vitro Toxicology 3, 309 (1990).
Smith, P. F. et al., Life Sciences 36, 1367 (1985).
Krundieck, C. L. et al., Analytical Biochemistry 104, 118 (1980).
Chapman, D. E. et al., Drug Metabolism and Disposition, 18, 929 (1990).
Balani Suresh K.
Lu Anthony Y. H.
Pitzenberger Steven M.
Ramjit Harri G.
Schwartz Michael S.
Caruso Charles M.
Merck & Co. , Inc.
Meredith Roy D.
Ramsuer Robert W.
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