Intravaginal contraceptive and drug release device and method fo

Details Intravaginal contraceptive and drug release device and method fo Intravaginal contraceptive and drug release device and method fo

1980-01-16

1981-06-23

Michell, Robert W.

Surgery

Respiratory method or device

Ozone or ion generation

128DIG8, A61F 1320

Patent

active

042744105

ABSTRACT:
A contraceptive device and method of contraception as well as a method of making the contraceptive device are described. Native collagen form of fibrillar protein is comminuted and homogenized in an acid environment; noncollagenous material is removed and residual collagen is mixed with water the pH of the resulting slurry is adjusted to 4.5 to 5.0 by the addition of acetic acid; gluteraldehyde is then added and the slurry poured into molds and frozen at approximately -10.degree. centigrade for approximately 20 hours. The frozen mass is then thawed, washed, and immersed in a wash of pH 8 to 9 for approximately 2 hours at 20.degree. centigrade. Sufficient reducing agent is added to the wash to create excess reducing equivalents. The sponge is then immersed in a buffer solution of pH 4 to 5 for a time sufficient to equilibrate to uniform pH. The sponge formed by the above method is then moistened and self-administered in the upper vault of the vagina proximal to the cervix. The sponge is then retained for a desired period, usually several days to one month.

REFERENCES:
patent: 2610625 (1952-09-01), Sifferd et al.
patent: 3094494 (1963-06-01), Hopkins et al.
patent: 3157524 (1964-11-01), Artandi
patent: 3639561 (1972-02-01), Gordon et al.
patent: 3780730 (1973-12-01), Weisman
patent: 4040417 (1977-08-01), Zipper

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