Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-08-27
1998-06-09
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514458, 424450, A61K 31685, A61K 31355, A61K 9127
Patent
active
057634238
ABSTRACT:
.alpha.-tocopherolphosphocholine and salts thereof have been discovered to possess anti-viral, anti-fungal, anti-inflammatory and PAF-antagonist activities. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal .alpha.-tocopherolphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising .alpha.-tocopherolphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise .alpha.-tocopherolphosphocholine or a salt thereof as a structural component of the liposome bilayer.
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Pruss Thaddeus P.
Yazdi Parvin T.
Clarion Pharmaeuticals Inc.
Conte, Esq. Salvatore R.
Kishore Gollamudi S.
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