Nasal administration of desmopressin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 15, A61K 3816, A61K 3821

Patent

active

057633983

ABSTRACT:
A pharmaceutical composition for single, effective and consistent plasma level, nasal administration of an aqueous solution of from about 5 to about 75 .mu.l and from about 0.2 to about 2.0 mg/ml of desmopressin acetate, a molarly corresponding amount of desmopressin or a pharmaceutically acceptable salt: of desmopressin. The composition is useful for the management of urinary disorders such as diabetes insipidus, incontinence, and nocturnal enuresis.

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Harris et al, "Effects of Concentration and Volume on Nasal Bioavailability and Biological Response to Desmopressin", Journal of Pharmaceutical Sciences, vol. 77, No. 4, Apr. 1988.

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