Serine protease variants having peptide ligase activity

Details Serine protease variants having peptide ligase activity Serine protease variants having peptide ligase activity

1994-06-08

1998-06-09

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435220, 435222, 935 10, 935 14, C12N 952, C12N 954, C12N 956

Patent

active

057632561

ABSTRACT:
The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.

REFERENCES:
patent: 4760025 (1988-07-01), Estell et al.
patent: 5155033 (1992-10-01), Estell et al.
Nakatsuka et al, J. Am. Chem. Soc., 1987, vol. 109, pp. 3808-3810.
Caldwell et al. Abst. of Pap. of Am. Chem. Soc., 1989, #MBTD73.

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