CDNA encoding a human ATP synthase Fo subunit (ASYSD)

Details CDNA encoding a human ATP synthase Fo subunit (ASYSD) CDNA encoding a human ATP synthase Fo subunit (ASYSD)

1997-10-09

1998-06-09

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 691, 43525233, 4353201, 435325, 536 231, 536 235, C12N 1500, C12N 1563, C12N 1585, C07H 7104

Patent

active

057632480

ABSTRACT:
The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.

REFERENCES:
Walker, J. et al., "The role of the stalk in the coupling mechanism of F.sub.1 F.sub.0 -ATPases", FEBS Letters, 346: 39-43 (1994).
Walker, J. et al.,"Identification of the subunits of F.sub.1 F.sub.0 -ATPase from bovine heart mitochondria", Biochemistry, 30: 5369-5378 (1991).
Motojima, K., et al., "cDNA cloning for and preparation of antibodies against subunit d of H.sup.+ -ATP synthase in rat mitochondria", Biochem. And Biophys. Res. Commun., 182: 1130-1138 (1992).
Walker, J. et al., "ATP Synthase from Bovine Mitochondria, The characterization and sequence analysis of two membrane-associated sub-units and of the corresponding cDNAs", J. Mol. Biol., 197: 89-100 (1987).
Database EST-STS on MPSRCH, accession number AA081285, Oct. 21, 1996.

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