DNA encoding arginyl tRNA synthetase from staphylococcus aureus

Details DNA encoding arginyl tRNA synthetase from staphylococcus aureus DNA encoding arginyl tRNA synthetase from staphylococcus aureus

1997-01-17

1998-06-09

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 435325, 4352523, 43525411, 536 232, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057632464

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141 PP. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc, Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Kazura, et al., "Differential Recognition of a Protective Filarial Antigen by Antibodies from Humans with Bancroftian Filariasis", J. Clin, Invest., 77, pp. 1985-1992 (1986).
Fraser et al, (1995) The Minimal Gene Complement of Mycoplasma genitalium, Science 270: 397-403.
Oguiza et al. (1993) A Gene Encoding Arginyl-tRNA Synthetase Is Located in the Upstream Region of the lysA Gene in Brevibacterium Iactofermentum: Regulation of argS-lysA Cluster Expression by Arginine. J. Bacteriol. 175(22): 7356-7362.

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