Phenylene, furyl, and thienyl leukotriene B.sub.4 analogues

Details Phenylene, furyl, and thienyl leukotriene B.sub.4 analogues Phenylene, furyl, and thienyl leukotriene B.sub.4 analogues

1987-06-26

1988-12-13

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514210, 514317, 514326, 514422, 514428, 514461, 514471, 514532, 514570, 514571, 514622, 546192, 546212, 546214, 548517, 548527, 548530, 548953, 548964, 548966, 549 77, 549 79, 549496, 549501, 560 55, 562470, 564170, A61K 3138, A61K 3134, C07D21108, C07D40900, C07D33322, C07C 6976, C07C 5948, C07C10326

Patent

active

047911336

ABSTRACT:
This invention relates to leukotriene B.sub.4 antagonists having the structure ##STR1## and the pharmaceutically acceptable addition salts thereof; wherein R.sup.1 is lower alkyl having 1-10 carbon atoms; or lower alkenyl or alkynyl having 2-10 carbon atoms; or lower alkadienyl having 3-10 carbon atoms; or lower alkadiynyl or alkenynyl having 4-10 carbon atoms;

REFERENCES:
patent: 4053466 (1977-10-01), Yoshimira et al.
patent: 4304783 (1981-12-01), Beck et al.
patent: 4309407 (1982-01-01), Lautenschlager
patent: 4546194 (1985-10-01), Miyano
patent: 4638011 (1987-01-01), Das
Biochem and Biophys. Res. Comm., 138, 540-546, (1986).
Lewis et al., J. Clin. Inves., 73, 889-897, (1984).
Bray, Brit. Medical Bull., 39, 249-254, (1983).

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