Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-02-02
1988-12-13
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142372, 514256, 514275, 514312, 514313, 514316, 514317, 514318, 514320, 514321, 514322, 514323, 514272, 546153, 546157, 546171, 546193, 546194, 546197, 546198, 546199, 546201, 546208, 546210, 544124, 544298, 544315, 544317, 544319, 544320, 544321, 544322, 544329, 544332, 544327, 544328, 544331, 544238, 544405, A61K 31435, A61K 31395, C07D21516, C07D40112, C07D23928
Patent
active
047911123
ABSTRACT:
N-heterocyclic-4-piperidyl-amides as analgesics and antagonists of opioids with respect to such undesirable side effects as respiratory depression.
Exemplary compounds have the formula ##STR1## in which formula R is a heterocyclic group, and R.sup.1 is a furanyl, thienyl, or lower alkoxy lower alkyl group, and R.sup.2 is a lower alkyl phenyl group.
REFERENCES:
patent: 4157393 (1979-06-01), Sanczuk et al.
patent: 4546105 (1985-10-01), Effland et al.
patent: 4584303 (1986-04-01), Huang et al.
Studies on Potent Analgesics, Youcheng et al., 3/81, 12 page article. (Acta Pharmaceutica Sinica) vol. XVI No. 3.
S. Grossmann et al., Pyridin-Analoga Des Fentanyls, 1978 6 page article, (Arch. Pharm. Weinheim).
Janssens et al., New Antihistiminic N-Heterocyclic 4-Piperidiamines 1985, 5 pages (J. Med. Chem) vol. 28, No. 12, pp. 1925-1947.
Youcheng et al., Structural Modification of 4-N-Propionyl Group, etc. 1983, 7 pages (Yaoxue Xuebo 18(8) 591-6.
Bagley Jerome R.
Spencer H. Kenneth
Cassett Larry R.
Konkol Chris P.
Lee Mary C.
Richter J.
The BOC Group Inc.
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