Process for preparing N-[5-(diphenylphosphinoylmethyl)-4-(4-fluo

Details Process for preparing N-[5-(diphenylphosphinoylmethyl)-4-(4-fluo Process for preparing N-[5-(diphenylphosphinoylmethyl)-4-(4-fluo

2000-03-09

2000-12-12

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544297, C07D 953

Patent

active

061601152

ABSTRACT:
N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2- yl]-N-methylmethanesulfonamide of the formula: ##STR1## is prepared by reaction of [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidi n-5-yl]methanol with chlorodiphenylphosphine. Compound I is an intermediate in the synthesis of pharmaceutically active compounds, in particular HMG--Co A. reductase inhibitors.

REFERENCES:
Bioorg. Med. Chem., 1997, 5, 437.

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