Formation of colloidal metal dispersions using aminodextrans as

Details Formation of colloidal metal dispersions using aminodextrans as Formation of colloidal metal dispersions using aminodextrans as

1992-01-29

1993-09-28

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

252 6253, 252 6254, 536121, 424 11, 424 71, 424 9, 424 858, 424 941, 424 943, 424 9467, 424460, 424461, 424491, 424493, 424617, 424618, 424646, 424649, C08B 3702, C07H 2300, A61K 4300, A61K 4900

Patent

active

052487725

ABSTRACT:
The invention related generally to the preparation of colloidal metal(O) particles having a crosslinked aminodextran coating with pendent amine groups attached thereto. The aminodextran acts as both a reductant for reducing metal ions to metal(O) particles and as the protective agent which coats the metal(O) particles thus formed. After stabilizing the aminodextran coating by use of a crosslinking agent, the coated particles can be used to covalently bind proteins. The resulting protein containing colloidal particles can be used as markers in optical and electron microscopy, in immunological and biological assays, and possibly as therapeutic agents.

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