Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-05-12
1993-09-28
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 514253, 514278, 514317, 514320, 514443, 514462, 514469, 544360, 544376, 544410, 546 19, 546187, 546196, 546202, 546205, 549 49, 549430, 549462, 564307, 564308, A61K 31445, C07D40504, C07D40904, C07D491113
Patent
active
052486869
ABSTRACT:
The invention relates to substituted arylamines and heteroarylamines, their preparation process and the pharmaceutical composition containing them. Said substituted amine is in accordance with the formula: ##STR1## in which R.sup.1 and R.sup.2 are optionally substituted alkyl radicals or form with N an optionally substituted piperazine or piperidine cycle, R.sup.3 and R.sup.4 represent a hydrogen atom or an organic radical, Y represents CR.sup.6 or N and R.sup.5 is an optionally substituted benzothiophenyl, benzofuranyl or naphthyl radical.
These amines can be used in pharmaceutical compositions for the treatment of nervous depression or for stimulating vigilance.
REFERENCES:
Thurkauf et al "Syntheis and . . . " J. Med Chem. 33 1452-1458 (1990, May).
Iorio et al "Nitrogen Analog of Phencyclidine" CA 101: 143552w (1984).
Chemical Abstracts, vol. 110, No. 17, Apr. 24, 1989, p. 78, resume No. 147750t, Columbus, Ohio; J. M. Sani et al., Interactions of Phencyclidine and Two Derivatives with Serotonergic Receptors, & Sigma Phencyclidine-Like Comd. Mol. Probes Biol., (Proc. U.S.-Fr. Sponsored Int. Semin., 2nd 1987 (Pub. 1988) 209-14.
Chemical Abstracts, vol. 109, No. 3, Jul. 18, 1988, p. 44, resume No. 16882u, Columbus, Ohio; J. Vignon et al.: "[3H]N-[1-(2Benzo(b)Thiophenyl)Cyclohexy] Piperidine ([3H]BTCP): A New Phencyclidine Analog Selective For The Dopamine Uptake Complex", & Eur. J. Pharmacol. 1988, 148(3), 427-36.
Chemical Abstracts, vol. 110, No. 23, Jun. 5, 1989, p. 53, resume No. 205446m, Columbus, Ohio; M. Slimani et al.: "Neurochemical and Behavioral Evidence For A Central Indirect Dopaminergic Agonist Activity of GK 13, A Phencyclidine Derivative", & Sigma Phencyclidine-Like Cmpd. Mol. Probes Biol., [Proc. U.S.-FR. Sponsored Int. Semin.] 2nd 1987 (Pub. 1988), 511-20.
Chicheportiche Robert
Costentin Jean
Kamenka Jean-Marc
Privat Alain
Centre National de la Recherche Scientifique
Chang Celia
Rotman Alan L.
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