Process for preparation of 4-isopropylphenol

Details Process for preparation of 4-isopropylphenol Process for preparation of 4-isopropylphenol

1983-12-02

1984-11-20

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568716, 568783, 568790, 568791, 568793, 568794, C07C 3748, C07C 3906

Patent

active

044840110

ABSTRACT:
The process for preparing 4-isopropylphenol (4-IPP) from 2-isopropylphenol (2-IPP) comprising contacting phenol with 2-IPP in the presence of a catalyst system selected from: (1) the combination of sulfuric acid on comminuted acid clay and a molecular sieve; and (2) trifluoromethane sulfonic acid (TFMSA); at a temperature of from about 90.degree. C. to about 250.degree. C., preferably from about 110.degree. C. to about 200.degree. C., wherein the initial mole ratio of phenol/2-IPP is from about 6 to about 2, preferably from about 4 to about 2.5, for a sufficient period to give a mole ratio of 4-IPP/2-IPP in the reaction system of from about 0.6 to about 1.5, and preferably from about 0.8 to about 1.2, without significant meta-isopropylphenol formation, i.e., less than about 10 mole %. In the isolation procedure, distillation separates the reaction mixture into phenol, 2-IPP, and 4-IPP.

REFERENCES:
patent: 2286953 (1942-06-01), Scott
patent: 3839470 (1974-10-01), Biller
patent: 3933927 (1976-01-01), Goodard
patent: 4200763 (1980-04-01), Dai
patent: 4339614 (1982-07-01), Olah
patent: 4423254 (1983-12-01), Olah

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